Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p321 | (1) | WCRB2014

Fetal overexposure to androgens, not estrogens, leaves a permanent legacy in terms of adrenal function in offspring

Ramaswamy Seshadri , Grace Cathal , Howie Forbes , Connolly Fiona , Konovalova Julia , McNeilly Alan S , Duncan W Colin , Rae Mick

Introduction: Overexposure to androgens during fetal life creates offspring with a polycystic ovary syndrome (PCOS)-like phenotype. Whether this phenotype is attributable to androgens during fetal life, or estrogens via maternal/placental metabolism, remains uncertain. The potential for in utero steroidal disruption of adrenal development and function is also unclear. We have examined the adrenal during development and adulthood in response to in utero androg...